Validity of Protein Structure Alignment Method Based on Backbone Torsion Angles

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Validity of Protein Structure Alignment Method Based on Backbone Torsion Angles

1Laboratory of Computational Biology & Bioinformatics, Institute of Health and Environment, Graduate School of Public Health, Seoul National University, 599 Gwanangno, Gwanak-gu, Seoul 151-742, Korea 2Interdisciplinary Graduate Program in Bioinformatics, College of Natural Science, Seoul National University, 599 Gwanangno, Gwanak-gu, Seoul 151-742, Korea †These authors equally contributed to th...

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TALI: Protein Structure Alignment Using Backbone Torsion Angles

This article introduces a novel protein structure alignment method (named TALI) based on protein backbone torsion angle instead of the more traditional distance matrix. Representing protein structure by a serial backbone torsion angles (φ, ψ), protein structure have a simple mapping relationship to protein sequence. Thus, TALI can naturally incorporate sequence information and sequence analysis...

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Real-value prediction of backbone torsion angles.

The backbone structure of a protein is largely determined by the phi and psi torsion angles. Thus, knowing these angles, even if approximately, will be very useful for protein-structure prediction. However, in a previous work, a sequence-based, real-value prediction of psi angle could only achieve a mean absolute error of 54 degrees (83 degrees, 35 degrees, 33 degrees for coil, strand, and heli...

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TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts.

NMR chemical shifts in proteins depend strongly on local structure. The program TALOS establishes an empirical relation between 13C, 15N and 1H chemical shifts and backbone torsion angles phi and psi (Cornilescu et al. J Biomol NMR 13 289-302, 1999). Extension of the original 20-protein database to 200 proteins increased the fraction of residues for which backbone angles could be predicted from...

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ژورنال

عنوان ژورنال: Journal of Proteomics & Bioinformatics

سال: 2011

ISSN: 0974-276X

DOI: 10.4172/jpb.1000192